Sustainability in urban logistics : a literature review

Purpose: The importance of urban logistics is on the rise. On the one hand, the population in cities is growing due to urbanization processes. On the other hand, there is a significant increase in the flow of goods (e.g., a boost in online purchases). Such changes are leading cities to face social, economic, and environmental issues, which urge to be addressed. Based on these premises, this study aims to identify, classify and provide an overview of the environmentally sustainable logistics solutions for urban contexts. Methodology: This study performs a systematic literature review. First, it provides a quantitative description of the results, highlighting eventual trends; second, it displays a narrative description of the papers considered to map the current solution and of the related methodology. Findings: The study highlights the maturity and interest in adopting more sustainable delivery options in urban logistics. The selection of suitable transport means, the engagement of stakeholders, as well as the definition of norms and regulations, emerge as the most discussed and promising solutions. Originality: This study is a first attempt to classify the existing body of knowledge related to urban logistics, analysing contributions based on different axes of classification and highlighting cutting-edge solutions to propose possible research directions

DMTs and Covid-19 severity in MS: a pooled analysis from Italy and France

We evaluated the effect of DMTs on Covid-19 severity in patients with MS, with a pooled-analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid-19 severity was assessed by multivariate ordinal-logistic models and pooled by a fixed-effect meta-analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti-CD20 therapies were significantly associated (OR = 2.05, 95%CI = 1.39–3.02, p < 0.001) with Covid-19 severity, whereas interferon indicated a decreased risk (OR = 0.42, 95%CI = 0.18–0.99, p = 0.047). This pooled-analysis confirms an increased risk of severe Covid-19 in patients on anti-CD20 therapies and supports the protective role of interferon

Innovative haematological parameters for early diagnosis of sepsis in adult patients admitted in intensive care unit

AIMS: This study was aimed to investigate the role of erythrocyte, platelet and reticulocyte (RET) parameters, measured by new haematological analyser Sysmex XN and C reactive protein (CRP), for early diagnosis of sepsis during intensive care unit (ICU) stay. METHODS: The study population consisted of 62 ICU patients, 21 of whom developed sepsis during ICU stay and 41 who did not. The performance for early diagnosing of sepsis was calculated as area under the curve (AUC) of receiver operating characteristics curves analysis. RESULTS: Compared with CRP (AUC 0.81), immature platelet fraction (IPF) (AUC 0.82) showed comparable efficiency for identifying the onset of sepsis. The association with the risk of developing sepsis during ICU stay was also assessed. One day before the onset of sepsis, a decreased of RET% was significantly associated with the risk of developing sepsis (OR=0.35, 95%\u2009CI 0.14 to 0.87), whereas an increased of IPF absolute value (IPF#) was significantly associated with the risk of developing sepsis (OR=1.13, 95%\u2009CI 1.03 to 1.24) 2\u2009days before the onset of sepsis. The value of CRP was not predictive of sepsis at either time points. CONCLUSIONS: IPF# and RET% may provide valuable clinical information for predicting the risk of developing sepsis, thus allowing early management of patients before the onset of clinically evident systemic infections